doctorxqx |
2011-01-17 17:10 |
一个疾病的名称,真的翻译不出来, 请高手指教……………… 以下是疾病介绍: Crystal Storing Histiocytocis In this rare condition there is massive accumulation of crystallized immunoglobulins in nodular collections of histiocytes77,78 (Fig. 4E). It is usually associated with plaa cell dyscrasias, monoclonal gammopathies, and other lymphoid neoplas. In these situations it may manifest as a systemic process (crystal storing histiocytosis), although it may also present as a mass lesion in the lung or other organs including the kidney, liver, and bone marrow among others. An association with collagen vascular disease (rheumatoid arthritis) has also been described. Immunohistochemically, the histiocytes have been shown to be positive for CD68, CD43, and lysosome, and weakly positive for k and l light chains, and IgM. S-100, B-cell and T-cell markers (CD20 and CD3), and cytokeratin stains are negative. In the context of an underlying lymphoproliferative disorder, the prognosis is thought to be poor, although in cases with an isolated pulmonary crystal storing histiocytoma, it may behave like a reactive entity with good prognosis.77 |
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